The mRNA vaccinated with 2+ doses have nearly 3x higher COVID-19 fatality rate than people with low IgG4 antibody levels
Three scientific papers form a solid evidence base showing that 2+ doses of Pfizer or Moderna vaccines increase COVID-19 infection fatality rate by nearly 3 times
A month ago, Igor Chudov wrote an article in which he explained that the booster-caused IgG4 immune tolerance explains excess mortality and "chronic covid". He used a new study which shows that:
“IgG4 antibodies among all spike-specific IgG antibodies rose, on average, from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination.“
Igor explained the role of these increased IgG4 antibodies in simple layman terms:
IgG4 antibodies have the opposite effect to all other types of antibodies and make our immune system ignore the particular antigen they are trained to detect.
How would “immune tolerance,” induced by repeat antigen shots such as mRNA injections, look like when the person is infected with Sars-Cov-2?
It would look like a “mild” infection without a serious fever that would last much longer than necessary and cause organ damage. The sufferer may say, for the first week, that they are thankful for vaccines and boosters making their symptoms mild. Then they start wondering why the infection is not going away.
mRNA vaccines increase serum IgG4 antibodies even after two doses
In a follow-up article three weeks later, Igor revisits the IgG4 issue by reviewing another even newer study.
He explains it nicely:
The main finding and the bad news is that mRNA vaccines induce immune tolerance, evidenced by IgG4 antibodies, even after two doses (initial “fully vaccinated” series).
Another good news is that for people who had previous Covid-19 infection (before vaccination), IgG4 also does NOT rise, even after mRNA injections:
So, the kinds of people most affected by IgG4 are infection-naive persons who got mRNA vaccinated before having their Covid-19 infection.
So, the knowledge generated by these two papers combined teaches us that people vaccinated with at least 2 mRNA shots without prior infection may have worse COVID-19 outcomes than the unvaccinated or vaccinated with prior infection.
But, how much worse? Thankfully, there is another paper that allows us to quantify the “how much worse“.
Serum IgG4 level predicts COVID-19 related mortality
That’s right. We come to the third very important paper with this same title published 16 months ago.
What does this paper teach us? First, let us point out that the authors did NOT investigate or mention vaccines at all. Why? Because they were only interested in the effect of IgG4 antibodies on COVID-19 mortality even before the vaccine rollout. What did they do?
One hundred twenty-eight consecutive patients (41 females, 31.3 %) referred to the Emergency Department of San Raffaele Hospital (Milan, Italy) for COVID-19 between June and December 2020 were included and prospectively followed-up.
Obviously, they conducted this study before the vaccine rollout. That is exactly why it provides invaluable insight into the effect of IgG4 antibodies on COVID-19 severity.
So, here is the most important conclusion and figure in the paper:
Specifically, a concentration of serum IgG4 > 700 mg/dl and an IgG4/IgG1 ratio > 0.05 were associated with a significantly increased mortality at 30-days (Fig. 1B)
Have a closer look at Fig. 1B. It shows that:
Patients with serum IgG4 level of >700mg/L had 3.65 higher COVID-19 mortality than those with serum IgG4 level of <700mg/L (statistically significant!)
Patients with IgG4/IgG1 > 0.05 had 2.7 higher COVID-19 mortality than those with IgG4/IgG1 < 0.05 (statistically significant!)
Now, let’s get back to the first paper above. Let’s recall what the researchers found about the IgG4/IgG1 ratio levels after the second and after the third mRNA dose. Here is Fig. 1C edited by me:
It is clear that the IgG4/IgG1 ratio exceeds 0.05 even after the second mRNA jab. This means that those people have almost 3-fold higher risk of dying from COVID-19 than those with IgG4/IgG1<0.05.
Since one of the papers cited here demonstrates that people WITH COVID infection prior to vaccination have not had increased IgG4 antibody levels, it implicitly follows that their risk is much lower than that of the 2+ dose vaccinated WITHOUT prior COVID infection.
Contribution of this analysis
This analysis has several conclusions and implications:
The evidence of immune tolerance caused by mRNA vaccine-increased IgG4 levels is additionally strengthened by combining knowledge from an older pre-vaccination study with two new studies inferring that vaccinated COVID-19 patients with increased IgG4 levels do have about 3 times increased fatality risk than those with low IgG4 levels.
People with prior infection without vaccination and people with infection prior to vaccination have much lower COVID-19 fatality risk due to non-existent immune tolerance, i.e. low IgG4 levels.
Further strengthening the case that those countries which had higher infection rates prior to vaccine rollout are NOW experiencing much lower excess mortality due to COVID-19 than those countries with immune naïve population prior to mass vaccinating their citizens.
Serum IgG4 levels are low in the unvaccinated without prior infection (who now represent a very tiny minority due to high seroprevalence after the 3-year long pandemic). So, even though we don’t have evidence, these people may fare even better when infected than the 2+ dose mRNA vaccinated with no infection prior to vaccination.